Pseudomonas aeruginosa PAO1, PA0035 (trpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0004834 tryptophan synthase activity
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
3127651 Reviewed by curator
Biological Process GO:0000162 tryptophan biosynthetic process
IDA
Inferred from Direct Assay
ECO:0000314
direct assay evidence used in manual assertion
3127651 Reviewed by curator
Biological Process GO:0000162 tryptophan biosynthetic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
3127651 Reviewed by curator
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
3127651 Reviewed by curator
Biological Process GO:0000162 tryptophan biosynthetic process
NAS
Non-traceable Author Statement
ECO:0000303
non-traceable author statement used in manual assertion
3127651 Reviewed by curator
Molecular Function GO:0004834 tryptophan synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00262
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF51366
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006568 tryptophan metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00262
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Phenylalanine, tyrosine and tryptophan biosynthesis ECO:0000037
not_recorded
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc COMPLETE-ARO-PWY superpathway of aromatic amino acid biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
PseudoCyc ALL-CHORISMATE-PWY superpathway of chorismate metabolism 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00400 Phenylalanine, tyrosine and tryptophan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc TRPSYN-PWY L-tryptophan biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
TIGRFAM TIGR00262 trpA: tryptophan synthase, alpha subunit IPR002028 Tryptophan synthase, alpha chain 8 259 9.3E-82
CDD cd04724 Tryptophan_synthase_alpha IPR002028 Tryptophan synthase, alpha chain 18 260 1.71341E-121
Hamap MF_00131 Tryptophan synthase alpha chain [trpA]. IPR002028 Tryptophan synthase, alpha chain 14 263 38.094
ProSitePatterns PS00167 Tryptophan synthase alpha chain signature. IPR018204 Tryptophan synthase, alpha chain, active site 48 61 -
Gene3D G3DSA:3.20.20.70 IPR013785 Aldolase-type TIM barrel 1 268 4.4E-103
SUPERFAMILY SSF51366 IPR011060 Ribulose-phosphate binding barrel 1 248 1.51E-92
Pfam PF00290 Tryptophan synthase alpha chain IPR002028 Tryptophan synthase, alpha chain 8 263 7.3E-105

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.