Pseudomonas aeruginosa PAO1, PA1254 (lhpC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0047425 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity
IDA
Inferred from Direct Assay 		ECO:0000005
enzyme assay evidence		 22833679 Reviewed by curator
Biological Process GO:0019470 4-hydroxyproline catabolic process
IDA
Inferred from Direct Assay 		ECO:0000005
enzyme assay evidence		 22833679 Reviewed by curator
Molecular Function GO:0016829 lyase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR12128
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Putative enzymes Other PAO1 genes in this class
Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00330 Arginine and proline metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc P4-PWY superpathway of L-lysine, L-threonine and L-methionine biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc DAPLYSINESYN-PWY L-lysine biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
CDD cd00408 DHDPS-like - - 10 290 6.32459E-93
PRINTS PR00146 Dihydrodipicolinate synthase signature IPR002220 DapA-like 40 61 1.2E-9
PRINTS PR00146 Dihydrodipicolinate synthase signature IPR002220 DapA-like 133 150 1.2E-9
SMART SM01130 DHDPS_2 IPR002220 DapA-like 6 294 5.4E-86
PRINTS PR00146 Dihydrodipicolinate synthase signature IPR002220 DapA-like 76 94 1.2E-9
Gene3D G3DSA:3.20.20.70 Aldolase class I IPR013785 Aldolase-type TIM barrel 4 295 4.8E-80
PIRSF PIRSF001365 DHDPS IPR002220 DapA-like 3 301 1.4E-75
PANTHER PTHR12128 DIHYDRODIPICOLINATE SYNTHASE IPR002220 DapA-like 4 293 6.3E-51
SUPERFAMILY SSF51569 Aldolase - - 3 292 4.5E-80
Pfam PF00701 Dihydrodipicolinate synthetase family IPR002220 DapA-like 8 291 5.1E-59
FunFam G3DSA:3.20.20.70:FF:000281 Probable dihydrodipicolinate synthetase - - 4 295 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.