Pseudomonas aeruginosa PAO1, PA1255 (lhpK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1255
Name
lhpK
Replicon chromosome
Genomic location 1363439 - 1364473 (- strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_249946.1
GI 15596452
Affymetrix PA1255_at
DNASU PaCD00006580
Entrez 881287
GenBank AAG04644.1
INSDC AAG04644.1
NCBI Locus Tag PA1255
protein_id(GenBank) gb|AAG04644.1|AE004555_4|gnl|PseudoCAP|PA1255
TIGR NTL03PA01256
UniParc UPI00000C52D1
UniProtKB Acc Q9I489
UniProtKB ID T3HPD_PSEAE
UniRef100 UniRef100_Q9I489
UniRef50 UniRef50_A9CH01
UniRef90 UniRef90_Q9I489

Product

Feature Type CDS
Coding Frame 1
Product Name
D-hydroxyproline epimerase, LhpK
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -4.86
Kyte-Doolittle Hydrophobicity Value -0.152
Molecular Weight (kDa) 37.3
Isoelectric Point (pI) 6.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 153 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001206 (807 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1255
Search term: lhpK

Human Homologs

Ensembl 110, assembly GRCh38.p14
trans-L-3-hydroxyproline dehydratase [Source:HGNC Symbol;Acc:HGNC:20488]
E-value: 4.7e-33
Percent Identity: 28.4

References

Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G, Lu CD
Microbiology (Reading) 2016 Jul;162(7):1232-1242
PubMed ID: 27145750