Pseudomonas aeruginosa PAO1, PA2403 (fpvG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2403
Name
fpvG
Replicon chromosome
Genomic location 2687497 - 2688708 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentPart ABC transporter complex FpvWXYZCDEF coded by operons fpvWXYZCDEF and fpvF.

Cross-References

RefSeq NP_251093.1
GI 15597599
Affymetrix PA2403_at
Entrez 878268
GenBank AAG05791.1
INSDC AAG05791.1
NCBI Locus Tag PA2403
protein_id(GenBank) gb|AAG05791.1|AE004668_1|gnl|PseudoCAP|PA2403
TIGR NTL03PA02403
UniParc UPI00000C56B3
UniProtKB Acc Q9I178
UniProtKB ID Q9I178_PSEAE
UniRef100 UniRef100_Q9I178
UniRef50 UniRef50_G8Q016
UniRef90 UniRef90_Q9I178

Product

Feature Type CDS
Coding Frame 1
Product Name
FpvG
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 11.41
Kyte-Doolittle Hydrophobicity Value 0.150
Molecular Weight (kDa) 45.1
Isoelectric Point (pI) 10.10

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 126 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003129 (482 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2403
Search term: fpvG
Search term: FpvG

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH.
Ganne G, Brillet K, Basta B, Roche B, Hoegy F, Gasser V, Schalk IJ
ACS Chem Biol 2017 Apr 21;12(4):1056-1065
PubMed ID: 28192658
The Two-Operon-Coded ABC Transporter Complex FpvWXYZCDEF is Required for Pseudomonas aeruginosa Growth and Virulence Under Iron-Limiting Conditions.
Gao L, Guo Z, Wang Y, Wang Y, Wang K, Li B, Shen L
J Membr Biol 2018 Feb;251(1):91-104
PubMed ID: 28975384