Pseudomonas aeruginosa PAO1, PA3523 (mexP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3523
Name
mexP
Replicon chromosome
Genomic location 3942650 - 3943807 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252213.1
GI 15598719
Affymetrix PA3523_at
DNASU PaCD00007550
Entrez 879790
GenBank AAG06911.1
INSDC AAG06911.1
NCBI Locus Tag PA3523
protein_id(GenBank) gb|AAG06911.1|AE004772_9|gnl|PseudoCAP|PA3523
TIGR NTL03PA03523
UniParc UPI00000C5A52
UniProtKB Acc Q9HY86
UniProtKB ID Q9HY86_PSEAE
UniRef100 UniRef100_Q4LDT7
UniRef50 UniRef50_Q4LDT7
UniRef90 UniRef90_Q4LDT7

Product

Feature Type CDS
Coding Frame 1
Product Name
MexP
Product Name Confidence: Class 3
Synonyms probable RND efflux membrane fusion protein precursor
probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor
Evidence for Translation
Charge (pH 7) 3.94
Kyte-Doolittle Hydrophobicity Value -0.114
Molecular Weight (kDa) 41.3
Isoelectric Point (pI) 9.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
mexP MexP is the membrane fusion protein of the MexPQ-OpmE multidrug efflux complex. [PMID:16301811] ARO:3003698 protein homolog model Perfect 726.9 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 422 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002142 (316 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3523
Search term: mexP
Search term: MexP

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa.
Mima T, Sekiya H, Mizushima T, Kuroda T, Tsuchiya T
Microbiol Immunol 2005;49(11):999-1002
PubMed ID: 16301811