Pseudomonas aeruginosa PAO1, PA4006 (nadD1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4006
Name
nadD1
Synonym: ybeN
Synonym: nadD
Replicon chromosome
Genomic location 4486203 - 4486847 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252695.1
GI 15599201
Affymetrix PA4006_at
Entrez 878969
GenBank AAG07393.1
INSDC AAG07393.1
NCBI Locus Tag PA4006
protein_id(GenBank) gb|AAG07393.1|AE004817_17|gnl|PseudoCAP|PA4006
TIGR NTL03PA04006
UniParc UPI000012FCB1
UniProtKB Acc Q9HX21
UniProtKB ID NADD_PSEAE
UniRef100 UniRef100_B7V8A6
UniRef50 UniRef50_Q4K5G0
UniRef90 UniRef90_A6V0A4

Product

Feature Type CDS
Coding Frame 1
Product Name
nicotinate mononucleotide adenylyltransferase NadD1
Product Name Confidence: Class 2
Synonyms nicotinic acid mononucleotide adenylyltransferase
NAD biosynthetic protein NadD
Evidence for Translation
Charge (pH 7) -2.90
Kyte-Doolittle Hydrophobicity Value -0.147
Molecular Weight (kDa) 23.8
Isoelectric Point (pI) 6.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1YUN TRANSFERASE 02/14/05 Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Pseudomonas aeruginosa Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 100.0
1YUL TRANSFERASE 02/14/05 Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Pseudomonas aeruginosa Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 100.0
1YUM TRANSFERASE 02/14/05 Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.7 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 514 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001677 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4006
Search term: nadD1

Human Homologs

References

Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene.
Mehl RA, Kinsland C, Begley TP
J Bacteriol 2000 Aug;182(15):4372-4
PubMed ID: 10894752
The complete genome sequence of Escherichia coli K-12.
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
Science 1997 Sep 5;277(5331):1453-62
PubMed ID: 9278503
Identification and characterization of YLR328W, the Saccharomyces cerevisiae structural gene encoding NMN adenylyltransferase. Expression and characterization of the recombinant enzyme.
Emanuelli M, Carnevali F, Lorenzi M, Raffaelli N, Amici A, Ruggieri S, Magni G
FEBS Lett 1999 Jul 16;455(1-2):13-7
PubMed ID: 10428462