Pseudomonas aeruginosa PAO1, PA4358 (feoB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4358
Name
feoB
Replicon chromosome
Genomic location 4884961 - 4887261 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253048.1
GI 15599554
Affymetrix PA4358_at
Entrez 881401
GenBank AAG07746.1
INSDC AAG07746.1
NCBI Locus Tag PA4358
protein_id(GenBank) gb|AAG07746.1|AE004851_14|gnl|PseudoCAP|PA4358
TIGR NTL03PA04359
UniParc UPI00000C5CDD
UniProtKB Acc Q9HW43
UniProtKB ID Q9HW43_PSEAE
UniRef100 UniRef100_Q9HW43
UniRef50 UniRef50_A6TF32
UniRef90 UniRef90_A6VB30

Product

Feature Type CDS
Coding Frame 1
Product Name
FeoB
Product Name Confidence: Class 1
Synonyms probable ferrous iron transport protein
Evidence for Translation
Charge (pH 7) -5.94
Kyte-Doolittle Hydrophobicity Value 0.469
Molecular Weight (kDa) 82.5
Isoelectric Point (pI) 6.03

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 445 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003951 (303 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4358
Search term: feoB
Search term: FeoB

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Escherichia coli K-12 ferrous iron uptake mutants are impaired in their ability to colonize the mouse intestine.
Stojiljkovic I, Cobeljic M, Hantke K
FEMS Microbiol Lett 1993 Mar 15;108(1):111-5
PubMed ID: 8472918
Characterization of the ferrous iron uptake system of Escherichia coli.
Kammler M, Schön C, Hantke K
J Bacteriol 1993 Oct;175(19):6212-9
PubMed ID: 8407793
Structural model of FeoB, the iron transporter from Pseudomonas aeruginosa, predicts a cysteine lined, GTP-gated pore.
Seyedmohammad S, Fuentealba NA, Marriott RA, Goetze TA, Edwardson JM, Barrera NP, Venter H
Biosci Rep 2016;36(2)
PubMed ID: 26934982