Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4674
|
Name |
Synonym: vapI |
Replicon | chromosome |
Genomic location | 5242254 - 5242559 (- strand) |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_253363.1 |
GI | 15599869 |
Affymetrix | PA4674_at |
DNASU | PaCD00008030 |
Entrez | 881405 |
GenBank | AAG08061.1 |
INSDC | AAG08061.1 |
NCBI Locus Tag | PA4674 |
protein_id(GenBank) | gb|AAG08061.1|AE004881_4|gnl|PseudoCAP|PA4674 |
TIGR | NTL03PA04675 |
UniParc | UPI00000C5DBA |
UniProtKB Acc | Q9HVC1 |
UniProtKB ID | Q9HVC1_PSEAE |
UniRef100 | UniRef100_Q9HVC1 |
UniRef50 | UniRef50_A6VCC3 |
UniRef90 | UniRef90_A6VCC3 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Antitoxin HigA
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -3.29 |
Kyte-Doolittle Hydrophobicity Value | -0.163 |
Molecular Weight (kDa) | 11.2 |
Isoelectric Point (pI) | 5.08 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6LB3 | ANTITOXIN/DNA | 11/13/19 | Crystal structure of PA4674 in complex with its operator DNA (18bp) from Pseudomonas aeruginosa | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); SYNTHETIC CONSTRUCT | 2.497 | X-RAY DIFFRACTION | 100.0 |
6JPI | ANTITOXIN/DNA | 03/27/19 | Crystal structure of PA4674 in complex with its operator DNA (28bp) from Pseudomonas aeruginosa | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); SYNTHETIC CONSTRUCT | 3.143 | X-RAY DIFFRACTION | 100.0 |
7CSW | ANTITOXIN/DNA | 08/17/20 | Pseudomonas aeruginosa antitoxin HigA with pa2440 promoter | Pseudomonas aeruginosa PAO1; Pseudomonas aeruginosa UCBPP-PA14 | 1.97 | X-RAY DIFFRACTION | 100.0 |
7CSV | ANTITOXIN | 08/17/20 | Pseudomonas aeruginosa antitoxin HigA | Pseudomonas aeruginosa PAO1 | 1.71 | X-RAY DIFFRACTION | 100.0 |
7CSY | ANTITOXIN/DNA | 08/17/20 | Pseudomonas aeruginosa antitoxin HigA with higBA promoter | Pseudomonas aeruginosa PAO1; Pseudomonas aeruginosa UCBPP-PA14 | 2.29 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 217 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004324 (343 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4674
Search term: Antitoxin HigA
|
Genetic organization of the duplicated vap region of the Dichelobacter nodosus genome.
Katz ME, Wright CL, Gartside TS, Cheetham BF, Doidge CV, Moses EK, Rood JI
J Bacteriol 1994 May;176(9):2663-9
PubMed ID: 8169216
|
The HigB/HigA toxin/antitoxin system of Pseudomonas aeruginosa influences the virulence factors pyochelin, pyocyanin, and biofilm formation.
Wood TL, Wood TK
Microbiologyopen 2016 Jun;5(3):499-511
PubMed ID: 26987441
|