Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA5325
|
Name |
sphA
|
Replicon | chromosome |
Genomic location | 5996036 - 5996986 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 4 transposon mutants in orthologs |
Comment | Loss of sphA leads to reduced survival in the murine lung and reduced resistance to the antimicrobial effect of sphingosine. |
RefSeq | NP_254012.1 |
GI | 15600518 |
Affymetrix | PA5325_at |
DNASU | PaCD00008300 |
Entrez | 880923 |
GenBank | AAG08710.1 |
INSDC | AAG08710.1 |
NCBI Locus Tag | PA5325 |
protein_id(GenBank) | gb|AAG08710.1|AE004945_4|gnl|PseudoCAP|PA5325 |
TIGR | NTL03PA05326 |
UniParc | UPI00000C5FA6 |
UniProtKB Acc | Q9HTN0 |
UniProtKB ID | Q9HTN0_PSEAE |
UniRef100 | UniRef100_W0Z1I2 |
UniRef50 | UniRef50_Q1I8G0 |
UniRef90 | UniRef90_A6VED2 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
SphA
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -7.41 |
Kyte-Doolittle Hydrophobicity Value | -0.263 |
Molecular Weight (kDa) | 35.5 |
Isoelectric Point (pI) | 5.21 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 60 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003078 (1032 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA5325
Search term: sphA
Search term: SphA
|
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
|
Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung.
LaBauve AE, Wargo MJ
PLoS Pathog 2014 Jan;10(1):e1003889
PubMed ID: 24465209
|
Crystal structure of a COG4313 outer membrane channel.
van den Berg B, Bhamidimarri SP, Winterhalter M
Sci Rep 2015 Jul 7;5:11927
PubMed ID: 26149193
|