Pseudomonas aeruginosa PAO1, PA0025 (aroE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006571 tyrosine biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 3277621 Reviewed by curator
Biological Process GO:0009094 L-phenylalanine biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 3277621 Reviewed by curator
Molecular Function GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 3277621 Reviewed by curator
Biological Process GO:0006520 cellular amino acid metabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 3277621 Reviewed by curator
Biological Process GO:0000162 tryptophan biosynthetic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 3277621 Reviewed by curator
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00507
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0019632 shikimate metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00507
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004764 shikimate 3-dehydrogenase (NADP+) activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00507
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCyc ALL-CHORISMATE-PWY superpathway of chorismate metabolism 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc ARO-PWY chorismate biosynthesis I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00400 Phenylalanine, tyrosine and tryptophan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-6163 chorismate biosynthesis from 3-dehydroquinate 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCAP Phenylalanine, tyrosine and tryptophan biosynthesis ECO:0000037
not_recorded
PseudoCyc COMPLETE-ARO-PWY superpathway of aromatic amino acid biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Hamap MF_00222 Shikimate dehydrogenase (NADP(+)) [aroE]. IPR022893 Shikimate dehydrogenase family 1 270 31.42564
FunFam G3DSA:3.40.50.720:FF:000104 Shikimate dehydrogenase (NADP(+)) - - 101 245 6.8E-60
SUPERFAMILY SSF53223 Aminoacid dehydrogenase-like, N-terminal domain IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily 1 100 1.09E-30
NCBIfam TIGR00507 JCVI: shikimate dehydrogenase IPR011342 Shikimate dehydrogenase 4 271 9.4E-76
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 101 270 1.25E-36
Pfam PF01488 Shikimate / quinate 5-dehydrogenase IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase 116 165 4.7E-7
CDD cd01065 NAD_bind_Shikimate_DH - - 100 255 2.5394E-40
Pfam PF18317 Shikimate 5'-dehydrogenase C-terminal domain IPR041121 SDH, C-terminal 238 267 3.4E-11
FunFam G3DSA:3.40.50.10860:FF:000006 Shikimate dehydrogenase (NADP(+)) - - 5 120 2.1E-42
Gene3D G3DSA:3.40.50.10860 Leucine Dehydrogenase, chain A, domain 1 - - 6 255 6.0E-87
Pfam PF08501 Shikimate dehydrogenase substrate binding domain IPR013708 Shikimate dehydrogenase substrate binding, N-terminal 6 87 5.5E-24
Gene3D G3DSA:3.40.50.720 - - - 101 245 6.0E-87
PANTHER PTHR21089 SHIKIMATE DEHYDROGENASE IPR022893 Shikimate dehydrogenase family 2 259 5.0E-60

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.