Pseudomonas aeruginosa UCBPP-PA14, PA14_00440 (trpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0000162 tryptophan biosynthetic process
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA0035
ECO:0000249
sequence similarity evidence used in automatic assertion
3127651
Molecular Function GO:0004834 tryptophan synthase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00290
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF51366
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0008152 metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF51366
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006568 tryptophan metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00290
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Amino acid biosynthesis and metabolism Other UCBPP-PA14 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pau01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00260 Glycine, serine and threonine metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
UniPathway UPA00035 L-tryptophan biosynthesis InterPro 5.8-49.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00400 Phenylalanine, tyrosine and tryptophan biosynthesis InterPro 5.8-49.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG (InterPro) 00260 Glycine, serine and threonine metabolism InterPro 5.8-49.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG pau01230 Biosynthesis of amino acids 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pau00400 Phenylalanine, tyrosine and tryptophan biosynthesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF00290 Tryptophan synthase alpha chain IPR002028 Tryptophan synthase, alpha chain 8 263 1.2E-104
Gene3D G3DSA:3.20.20.70 IPR013785 Aldolase-type TIM barrel 2 268 1.1E-85
ProSitePatterns PS00167 Tryptophan synthase alpha chain signature. IPR018204 Tryptophan synthase, alpha chain, active site 48 61 -
TIGRFAM TIGR00262 trpA: tryptophan synthase, alpha subunit IPR002028 Tryptophan synthase, alpha chain 8 259 2.0E-81
CDD cd04724 Tryptophan_synthase_alpha IPR002028 Tryptophan synthase, alpha chain 18 260 9.84355E-122
SUPERFAMILY SSF51366 IPR011060 Ribulose-phosphate binding barrel 1 248 1.51E-92
Hamap MF_00131 Tryptophan synthase alpha chain [trpA]. IPR002028 Tryptophan synthase, alpha chain 14 263 38.076

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.