Pseudomonas aeruginosa UCBPP-PA14, PA14_09870 (eftM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_09870
Name
eftM
Replicon chromosome
Genomic location 848003 - 848746 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_788936.1
GI 116052220
Entrez 4382193
INSDC ABJ13456.1
NCBI Locus Tag PA14_09870
UniParc UPI00003962D9
UniProtKB Acc Q02T00
UniProtKB ID Q02T00_PSEAB
UniRef100 UniRef100_Q02T00
UniRef50 UniRef50_Q5E5R1
UniRef90 UniRef90_W0YY28

Product

Feature Type CDS
Coding Frame 1
Product Name
SAM-dependent methyltransferase , EftM
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -4.64
Kyte-Doolittle Hydrophobicity Value -0.357
Molecular Weight (kDa) 28.1
Isoelectric Point (pI) 6.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 139 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001521 (347 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_09870
Search term: eftM

Human Homologs

References

Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.
Owings JP, Kuiper EG, Prezioso SM, Meisner J, Varga JJ, Zelinskaya N, Dammer EB, Duong DM, Seyfried NT, Albertí S, Conn GL, Goldberg JB
J Biol Chem 2016 Feb 12;291(7):3280-90
PubMed ID: 26677219
Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia.
Barbier M, Owings JP, Martínez-Ramos I, Damron FH, Gomila R, Blázquez J, Goldberg JB, Albertí S
mBio 2013 May 7;4(3):e00207-13
PubMed ID: 23653444