Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_19490
|
Name |
Synonym: ahpC2 |
Replicon | chromosome |
Genomic location | 1684916 - 1685554 (+ strand) |
Transposon Mutants | 1 transposon mutants in UCBPP-PA14 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
Comment | Referred to as AhpC2 in PMID:34315109 |
RefSeq | YP_789697.1 |
GI | 116051470 |
Entrez | 4385236 |
INSDC | ABJ12706.1 |
NCBI Locus Tag | PA14_19490 |
UniParc | UPI00003960B2 |
UniProtKB Acc | Q02QT9 |
UniProtKB ID | Q02QT9_PSEAB |
UniRef100 | UniRef100_A0A071KYB2 |
UniRef50 | UniRef50_Q54SE2 |
UniRef90 | UniRef90_A0A024HLA3 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
1-Cys peroxiredoxin LsfA
|
Synonyms |
antioxidant protein |
Evidence for Translation | |
Charge (pH 7) | -5.83 |
Kyte-Doolittle Hydrophobicity Value | -0.423 |
Molecular Weight (kDa) | 24.2 |
Isoelectric Point (pI) | 5.15 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
7KUU | OXIDOREDUCTASE | 11/25/20 | LsfA from P. aeruginosa, a 1-Cys Prx in Sulfonic acid form | Pseudomonas aeruginosa (strain UCBPP-PA14) | 2 | X-RAY DIFFRACTION | 100.0 |
6P0W | OXIDOREDUCTASE | 05/17/19 | LsfA from P. aeruginosa, a 1-Cys Prx in reduced form | Pseudomonas aeruginosa (strain UCBPP-PA14) | 2.4 | X-RAY DIFFRACTION | 100.0 |
Source 1 | |
Database | PseudoCAP |
Category | 1-Cys peroxyredoxin |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Mus musculus |
Notes | Mice infected with lsfA C45A mutant strain showed a reduced bacterial burden in all organs analyzed compared with wild-type PA14-infected |
Infection model | in vitro infection of J774 macrophages |
Infection model | Mouse acute pneumonia model (host |
Reference | 25329795 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 592 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002190 (528 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_19490
Search term: 1-Cys peroxiredoxin LsfA
|
Ensembl
110, assembly
GRCh38.p14
|
peroxiredoxin 6 [Source:HGNC Symbol;Acc:HGNC:16753]
E-value:
3.3e-61
Percent Identity:
52.9
|
Peroxiredoxin AhpC1 protects Pseudomonas aeruginosa against the inflammatory oxidative burst and confers virulence.
Rocha LS, Silva BPD, Correia TML, Silva RPD, Meireles DA, Pereira R, Netto LES, Meotti FC, Queiroz RF
Redox Biol 2021 Oct;46:102075
PubMed ID: 34315109
|