Pseudomonas aeruginosa UCBPP-PA14, PA14_64190 (fis)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_64190
Name
fis
Replicon chromosome
Genomic location 5719308 - 5719631 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14

Cross-References

RefSeq YP_793319.1
GI 116053001
Entrez 4383322
INSDC ABJ14237.1
NCBI Locus Tag PA14_64190
UniParc UPI0000165ED8
UniProtKB Acc Q02FG7
UniProtKB ID Q02FG7_PSEAB
UniRef100 UniRef100_Q9HUW0
UniRef50 UniRef50_Q9HUW0
UniRef90 UniRef90_Q9HUW0

Product

Feature Type CDS
Coding Frame 1
Product Name
DNA-binding protein Fis
Synonyms
Evidence for Translation
Charge (pH 7) -1.08
Kyte-Doolittle Hydrophobicity Value -0.439
Molecular Weight (kDa) 11.9
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6M10 DNA BINDING PROTEIN 02/24/20 Crystal structure of PA4853 (Fis) from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 2.985 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 198 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004482 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_64190
Search term: fis

Human Homologs

References

Fis Regulates Type III Secretion System by Influencing the Transcription of exsA in Pseudomonas aeruginosa Strain PA14.
Deng X, Li M, Pan X, Zheng R, Liu C, Chen F, Liu X, Cheng Z, Jin S, Wu W
Front Microbiol 2017;8:669
PubMed ID: 28469612