Pseudomonas entomophila L48, PSEEN1550 (aprA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0042783 evasion of host immune response
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 16789834 Reviewed by curator
Molecular Function GO:0008233 peptidase activity
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 16789834 Reviewed by curator
Cellular Component GO:0005576 extracellular region
IDA
Inferred from Direct Assay 		ECO:0000333
sodium dodecyl sulfate polyacrylamide gel electrophoresis evidence		 16789834 Reviewed by curator
Cellular Component GO:0005615 extracellular space
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF08548
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008270 zinc ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005509 calcium ion binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00353
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004222 metalloendopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006508 proteolysis
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF001205
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0008237 metallopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:G3DSA:3.40.390.10
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pen01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF08548 Peptidase M10 serralysin C terminal IPR013858 Peptidase M10 serralysin, C-terminal 263 485 6.8E-79
PRINTS PR00313 NodO calcium binding signature - - 345 356 2.9E-12
Pfam PF13583 Metallo-peptidase family M12B Reprolysin-like - - 175 240 2.8E-6
PRINTS PR00313 NodO calcium binding signature - - 375 383 2.9E-12
Gene3D G3DSA:3.40.390.10 Collagenase (Catalytic Domain) IPR024079 Metallopeptidase, catalytic domain superfamily 37 265 0.0
FunFam G3DSA:3.40.390.10:FF:000046 Serralysin - - 36 265 4.8E-116
PRINTS PR00313 NodO calcium binding signature - - 366 374 2.9E-12
SUPERFAMILY SSF55486 Metalloproteases ("zincins"), catalytic domain - - 27 261 3.42E-66
PRINTS PR00313 NodO calcium binding signature - - 384 393 2.9E-12
NCBIfam NF035945 NCBIFAM: serralysin family metalloprotease - - 24 485 0.0
PIRSF PIRSF001205 Serralysin IPR016294 Peptidase M10B 5 485 0.0
PANTHER PTHR10201 MATRIX METALLOPROTEINASE - - 74 285 4.9E-9
Pfam PF00353 RTX calcium-binding nonapeptide repeat (4 copies) IPR001343 RTX calcium-binding nonapeptide repeat 356 390 6.6E-10
SMART SM00235 col_5 IPR006026 Peptidase, metallopeptidase 79 243 1.4E-19
SUPERFAMILY SSF51120 beta-Roll IPR011049 Serralysin-like metalloprotease, C-terminal 263 484 3.79E-49
CDD cd04277 ZnMc_serralysin_like IPR034033 Serralysin-like metallopeptidase domain 72 262 7.04096E-43
FunFam G3DSA:2.150.10.10:FF:000001 Serralysin - - 260 482 1.3E-116
Gene3D G3DSA:2.150.10.10 - IPR011049 Serralysin-like metalloprotease, C-terminal 31 482 0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.