Pseudomonas aeruginosa PAO1, PA0058 (dsbM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0058
Name
dsbM
Replicon chromosome
Genomic location 72680 - 73384 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_248748.1
GI 15595256
Affymetrix PA0058_at
DNASU PaCD00006025
Entrez 880931
GenBank AAG03448.1
INSDC AAG03448.1
NCBI Locus Tag PA0058
protein_id(GenBank) gb|AAG03448.1|AE004445_9|gnl|PseudoCAP|PA0058
TIGR NTL03PA00059
UniParc UPI00000C4F0B
UniProtKB Acc Q9I774
UniProtKB ID Q9I774_PSEAE
UniRef100 UniRef100_Q9I774
UniRef50 UniRef50_V5UEA6
UniRef90 UniRef90_Z2DKX5

Product

Feature Type CDS
Coding Frame 1
Product Name
DsbM
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -5.74
Kyte-Doolittle Hydrophobicity Value 0.003
Molecular Weight (kDa) 24.9
Isoelectric Point (pI) 5.29

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5HFI OXIDOREDUCTASE 01/07/16 Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa with GSH PSEUDOMONAS AERUGINOSA PAO1 1.801 X-RAY DIFFRACTION 100.0
5HFG OXIDOREDUCTASE 01/07/16 Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA PAO1 1.823 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 83 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000057 (376 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0058
Search term: dsbM
Search term: DsbM

Transposon Insertions in PAO1

Type ISphoA/hah insertion site
Mutant ID UWGC: 37097
Genomic Position 72842
Position in ORF 163(705)
Reference 14617778

Transposon Insertions in Orthologs

References

DsbM, a novel disulfide oxidoreductase affects aminoglycoside resistance in Pseudomonas aeruginosa by OxyR-regulated response.
Wang X, Li M, Liu L, Mou R, Zhang X, Bai Y, Xu H, Qiao M
J. Microbiol. 2012 Dec;50(6):932-8
PubMed ID: 23274979