Pseudomonas aeruginosa PAO1, PA0073 (tagT1)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 86284 - 87003 (- strand)
Transposon Mutants 2 transposon mutants in PAO1


RefSeq NP_248763.1
GI 15595271
Affymetrix PA0073_at
DNASU PaCD00006032
Entrez 878396
GenBank AAG03463.1
INSDC AAG03463.1
NCBI Locus Tag PA0073
protein_id(GenBank) gb|AAG03463.1|AE004446_11|gnl|PseudoCAP|PA0073
UniParc UPI00000C4F1A
UniProtKB Acc Q9I759
UniRef100 UniRef100_W0YKU8
UniRef50 UniRef50_F6AF48
UniRef90 UniRef90_A6UXK5


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 2
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.05
Kyte-Doolittle Hydrophobicity Value -0.101
Molecular Weight (kDa) 26.0
Isoelectric Point (pI) 8.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database Victors : 4220
Category Not available / Not known
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Infection model Rat agar bead model of chronic lung infection
Reference 14641575
Source 2
Database VFDB : VF0334
Category Hcp secretion island-1 encoded type VI secretion system (H-T6SS)
Evidence ECO:0000305
curator inference used in manual assertion
Host Organism
Reference 16763151

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000072 (430 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA0073
Search term: tagT1
Search term: TagT1

Human Homologs

Ensembl 86, assembly GRCh38.p7
ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45]
E-value: 1.6e-14
Percent Identity: 31.6

Transposon Insertions in PAO1

Type ISphoA/hah insertion site
Mutant ID UWGC: 40995
Genomic Position 86902
Position in ORF 619(720)
Reference 14617778
Type Confirmed ISlacZ/hah insertion site
Mutant ID UWGC: 9431
Genomic Position 86767
Position in ORF 484(720)
Reference 14617778

Transposon Insertions in Orthologs


A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria.
Hood RD, Singh P, Hsu F, Güvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, Mougous JD
Cell Host Microbe 2010 Jan;7(1):25-37
PubMed ID: 20114026
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology (Reading, Engl.) 2007 Aug;153(Pt 8):2689-99
PubMed ID: 17660433