Pseudomonas aeruginosa PAO1, PA0290

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0290
Name
Replicon chromosome
Genomic location 325700 - 326671 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248981.1
GI 15595487
Affymetrix PA0290_at
Entrez 880764
GenBank AAG03679.1
INSDC AAG03679.1
NCBI Locus Tag PA0290
protein_id(GenBank) gb|AAG03679.1|AE004467_1|gnl|PseudoCAP|PA0290
TIGR NTL03PA00291
UniParc UPI00000C4FE6
UniProtKB Acc Q9I6K0
UniProtKB ID Q9I6K0_PSEAE
UniRef100 UniRef100_W0YMM2
UniRef50 UniRef50_I7B5R5
UniRef90 UniRef90_A6UY91

Product

Feature Type CDS
Coding Frame 1
Product Name
putative diguanylate cyclase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -12.14
Kyte-Doolittle Hydrophobicity Value -0.364
Molecular Weight (kDa) 36.4
Isoelectric Point (pI) 4.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 503 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000287 (512 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0290

Human Homologs

References

Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus.
Hecht GB, Newton A
J Bacteriol 1995 Nov;177(21):6223-9
PubMed ID: 7592388
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S
Proc Natl Acad Sci U S A 2006 Feb 21;103(8):2839-44
PubMed ID: 16477007
Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses.
Wei Q, Leclercq S, Bhasme P, Xu A, Zhu B, Zhang Y, Zhang M, Wang S, Ma LZ
Appl Environ Microbiol 2019 Nov 1;85(21)
PubMed ID: 31444209