Pseudomonas aeruginosa PAO1, PA0374 (ftsE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0374
Name
ftsE
Replicon chromosome
Genomic location 418891 - 419562 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249065.1
GI 15595571
Affymetrix PA0374_ftsE_at
DNASU PaCD00006159
Entrez 883078
GenBank AAG03763.1
INSDC AAG03763.1
NCBI Locus Tag PA0374
protein_id(GenBank) gb|AAG03763.1|AE004475_5|gnl|PseudoCAP|PA0374
TIGR NTL03PA00375
UniParc UPI00000C5032
UniProtKB Acc Q9I6C0
UniProtKB ID Q9I6C0_PSEAE
UniRef100 UniRef100_Q9I6C0
UniRef50 UniRef50_A0A085JP85
UniRef90 UniRef90_Q9I6C0

Product

Feature Type CDS
Coding Frame 1
Product Name
cell division protein FtsE
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 7.92
Kyte-Doolittle Hydrophobicity Value -0.093
Molecular Weight (kDa) 24.6
Isoelectric Point (pI) 10.84

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8I6R MEMBRANE PROTEIN 01/29/23 Cryo-EM structure of Pseudomonas aeruginosa FtsE(E163Q)X/EnvC complex with ATP in peptidisc Pseudomonas aeruginosa 4.0 ELECTRON MICROSCOPY 99.6
8I6S MEMBRANE PROTEIN 01/29/23 Cryo-EM structure of Pseudomonas aeruginosa FtsE(E163Q)X/EnvC complex with ATP in peptidisc Pseudomonas aeruginosa 4.4 ELECTRON MICROSCOPY 99.6
8I6Q MEMBRANE PROTEIN 01/29/23 Cryo-EM structure of Pseudomonas aeruginosa FtsE(WT)X complex in peptidisc Pseudomonas aeruginosa 4.23 ELECTRON MICROSCOPY 100.0
8I6O MEMBRANE PROTEIN 01/29/23 Cryo-EM structure of Pseudomonas aeruginosa FtsE(WT)X/EnvC complex in peptidisc Pseudomonas aeruginosa 3.8 ELECTRON MICROSCOPY 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000365 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0374
Search term: ftsE

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 6 (Langereis blood group) [Source:HGNC Symbol;Acc:HGNC:47]
E-value: 9.2e-22
Percent Identity: 34.6
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 6 (Langereis blood group) [Source:HGNC Symbol;Acc:HGNC:47]
E-value: 9.2e-22
Percent Identity: 34.6

References

Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.
Sofia HJ, Burland V, Daniels DL, Plunkett G 3rd, Blattner FR
Nucleic Acids Res 1994 Jul 11;22(13):2576-86
PubMed ID: 8041620
Molecular characterization of Escherichia coli FtsE and FtsX.
de Leeuw E, Graham B, Phillips GJ, ten Hagen-Jongman CM, Oudega B, Luirink J
Mol Microbiol 1999 Feb;31(3):983-93
PubMed ID: 10048040