Pseudomonas aeruginosa PAO1, PA0397

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0397
Name
Synonym: czcD
Replicon chromosome
Genomic location 438938 - 439837 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249088.1
GI 15595594
Affymetrix PA0397_at
DNASU PaCD00006171
Entrez 878314
GenBank AAG03786.1
INSDC AAG03786.1
NCBI Locus Tag PA0397
protein_id(GenBank) gb|AAG03786.1|AE004477_3|gnl|PseudoCAP|PA0397
TIGR NTL03PA00398
UniParc UPI00000C503F
UniProtKB Acc Q9I6A3
UniProtKB ID Q9I6A3_PSEAE
UniRef100 UniRef100_W0YKE7
UniRef50 UniRef50_B4RIN0
UniRef90 UniRef90_V6A7V1

Product

Feature Type CDS
Coding Frame 1
Product Name
probable cation efflux system protein
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -6.63
Kyte-Doolittle Hydrophobicity Value 0.619
Molecular Weight (kDa) 32.4
Isoelectric Point (pI) 5.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6VD8 TRANSPORT PROTEIN 12/23/19 Metal-bound C-terminal domain of CzcD transporter from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.3 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 587 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000388 (818 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0397

Human Homologs

Ensembl 110, assembly GRCh38.p14
solute carrier family 30 member 8 [Source:HGNC Symbol;Acc:HGNC:20303]
E-value: 9.4e-30
Percent Identity: 29.1
Ensembl 110, assembly GRCh38.p14
solute carrier family 30 member 8 [Source:HGNC Symbol;Acc:HGNC:20303]
E-value: 9.4e-30
Percent Identity: 29.1
Ensembl 110, assembly GRCh38.p14
solute carrier family 30 member 8 [Source:HGNC Symbol;Acc:HGNC:20303]
E-value: 9.4e-30
Percent Identity: 29.1
Ensembl 110, assembly GRCh38.p14
solute carrier family 30 member 8 [Source:HGNC Symbol;Acc:HGNC:20303]
E-value: 9.4e-30
Percent Identity: 29.1

References

Expression and nucleotide sequence of a plasmid-determined divalent cation efflux system from Alcaligenes eutrophus.
Nies DH, Nies A, Chu L, Silver S
Proc Natl Acad Sci U S A 1989 Oct;86(19):7351-5
PubMed ID: 2678100