Pseudomonas aeruginosa PAO1, PA0470 (fiuA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0470
Name
fiuA
Synonym: fiuA
Replicon chromosome
Genomic location 530029 - 532437 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 13 transposon mutants in orthologs

Cross-References

RefSeq NP_249161.1
GI 15595667
Affymetrix PA0470_at
Entrez 880545
GenBank AAG03859.1
INSDC AAG03859.1
NCBI Locus Tag PA0470
protein_id(GenBank) gb|AAG03859.1|AE004484_11|gnl|PseudoCAP|PA0470
TIGR NTL03PA00471
UniParc UPI00000C5074
UniProtKB Acc Q9I648
UniProtKB ID Q9I648_PSEAE
UniRef100 UniRef100_Q9I648
UniRef50 UniRef50_Q9I648
UniRef90 UniRef90_Q9I648

Product

Feature Type CDS
Coding Frame 1
Product Name
Ferrichrome receptor FiuA
Product Name Confidence: Class 1
Synonyms Ferrichrome receptor FiuA
Evidence for Translation
Charge (pH 7) -11.16
Kyte-Doolittle Hydrophobicity Value -0.480
Molecular Weight (kDa) 88.2
Isoelectric Point (pI) 5.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 1
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 295 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000149 (2669 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0470
Search term: fiuA

Human Homologs

References

Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes.
Ochsner UA, Vasil ML
Proc Natl Acad Sci U S A 1996 Apr 30;93(9):4409-14
PubMed ID: 8633080
Identification of a new site for ferrichrome transport by comparison of the FhuA proteins of Escherichia coli, Salmonella paratyphi B, Salmonella typhimurium, and Pantoea agglomerans.
Killmann H, Herrmann C, Wolff H, Braun V
J Bacteriol 1998 Aug;180(15):3845-52
PubMed ID: 9683481
The heterologous siderophores ferrioxamine B and ferrichrome activate signaling pathways in Pseudomonas aeruginosa.
Llamas MA, Sparrius M, Kloet R, Jiménez CR, Vandenbroucke-Grauls C, Bitter W
J Bacteriol 2006 Mar;188(5):1882-91
PubMed ID: 16484199