Pseudomonas aeruginosa PAO1, PA1058 (shaE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1058
Name
shaE
Synonym: phaF
Replicon chromosome
Genomic location 1147202 - 1147471 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249749.1
GI 15596255
Affymetrix PA1058_at
Entrez 881139
GenBank AAG04447.1
INSDC AAG04447.1
NCBI Locus Tag PA1058
protein_id(GenBank) gb|AAG04447.1|AE004537_12|gnl|PseudoCAP|PA1058
TIGR NTL03PA01059
UniParc UPI00000C522C
UniProtKB Acc Q9I4R6
UniProtKB ID Q9I4R6_PSEAE
UniRef100 UniRef100_W0YN88
UniRef50 UniRef50_Q47XJ3
UniRef90 UniRef90_Q02IM5

Product

Feature Type CDS
Coding Frame 1
Product Name
ShaE
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -1.08
Kyte-Doolittle Hydrophobicity Value 1.333
Molecular Weight (kDa) 9.6
Isoelectric Point (pI) 4.77

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 195 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001020 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1058
Search term: shaE
Search term: ShaE

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Characterization of a multigene-encoded sodium/hydrogen antiporter (sha) from Pseudomonas aeruginosa: its involvement in pathogenesis.
Kosono S, Haga K, Tomizawa R, Kajiyama Y, Hatano K, Takeda S, Wakai Y, Hino M, Kudo T
J Bacteriol 2005 Aug;187(15):5242-8
PubMed ID: 16030218