Pseudomonas aeruginosa PAO1, PA1165 (pcpS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1165
Name
pcpS
Replicon chromosome
Genomic location 1264191 - 1264919 (- strand)

Cross-References

RefSeq NP_249856.1
GI 15596362
Affymetrix PA1165_at
DNASU PaCD00006535
Entrez 878433
GenBank AAG04554.1
INSDC AAG04554.1
NCBI Locus Tag PA1165
protein_id(GenBank) gb|AAG04554.1|AE004546_9|gnl|PseudoCAP|PA1165
TIGR NTL03PA01166
UniParc UPI00000C5283
UniProtKB Acc Q9I4H2
UniProtKB ID Q9I4H2_PSEAE
UniRef100 UniRef100_Q9I4H2
UniRef50 UniRef50_Q9I4H2
UniRef90 UniRef90_Q9I4H2

Product

Feature Type CDS
Coding Frame 1
Product Name
PcpS
Product Name Confidence: Class 1
Synonyms Pseudomonas aeruginosa carrier protein synthase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.10
Kyte-Doolittle Hydrophobicity Value -0.037
Molecular Weight (kDa) 26.7
Isoelectric Point (pI) 6.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7BCZ TRANSFERASE 12/21/20 Structure of the 4'-phosphopantetheinyl transferase PcpS from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.4 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 88 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001123 (532 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1165
Search term: pcpS
Search term: PcpS

Human Homologs

References

The Escherichia coli enterobactin biosynthesis gene, entD: nucleotide sequence and membrane localization of its protein product.
Armstrong SK, Pettis GS, Forrester LJ, McIntosh MA
Mol Microbiol 1989 Jun;3(6):757-66
PubMed ID: 2526281
The entD gene of the Escherichia coli K12 enterobactin gene cluster.
Coderre PE, Earhart CF
J Gen Microbiol 1989 Nov;135(11):3043-55
PubMed ID: 2533240