Pseudomonas aeruginosa PAO1, PA1292

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1292
Name
Replicon chromosome
Genomic location 1402981 - 1403835 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249983.1
GI 15596489
Affymetrix PA1292_at
DNASU PaCD00006595
Entrez 881495
GenBank AAG04681.1
INSDC AAG04681.1
NCBI Locus Tag PA1292
protein_id(GenBank) gb|AAG04681.1|AE004558_10|gnl|PseudoCAP|PA1292
TIGR NTL03PA01293
UniParc UPI0000136F11
UniProtKB Acc Q9I452
UniProtKB ID THTM_PSEAE
UniRef100 UniRef100_Q9I452
UniRef50 UniRef50_Q9I452
UniRef90 UniRef90_Q9I452

Product

Feature Type CDS
Coding Frame 1
Product Name
probable 3-mercaptopyruvate sulfurtransferase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.44
Kyte-Doolittle Hydrophobicity Value -0.132
Molecular Weight (kDa) 30.6
Isoelectric Point (pI) 5.31

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 383 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001236 (522 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1292

Human Homologs

References

Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mutagenesis.
Nagahara N, Okazaki T, Nishino T
J Biol Chem 1995 Jul 7;270(27):16230-5
PubMed ID: 7608189
Role of amino acid residues in the active site of rat liver mercaptopyruvate sulfurtransferase. CDNA cloning, overexpression, and site-directed mutagenesis.
Nagahara N, Nishino T
J Biol Chem 1996 Nov 1;271(44):27395-401
PubMed ID: 8910318