Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA1361
|
Name |
norM
Synonym: norM Synonym: ydhE Synonym: pmpM |
Replicon | chromosome |
Genomic location | 1472547 - 1473980 (- strand) |
Transposon Mutants | 3 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_250052.1 |
GI | 15596558 |
Affymetrix | PA1361_at |
Entrez | 880959 |
GenBank | AAG04750.1 |
INSDC | AAG04750.1 |
NCBI Locus Tag | PA1361 |
protein_id(GenBank) | gb|AAG04750.1|AE004565_9|gnl|PseudoCAP|PA1361 |
TIGR | NTL03PA01362 |
UniParc | UPI0000130361 |
UniProtKB Acc | Q9I3Y3 |
UniProtKB ID | PMPM_PSEAE |
UniRef100 | UniRef100_Q9I3Y3 |
UniRef50 | UniRef50_Q9I3Y3 |
UniRef90 | UniRef90_Q9I3Y3 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
NorM
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | 12.55 |
Kyte-Doolittle Hydrophobicity Value | 0.632 |
Molecular Weight (kDa) | 50.8 |
Isoelectric Point (pI) | 9.99 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
PmpM | PmpM is a multidrug efflux pump belonging to the MATE family of Pseudomonas aeruginosa. PmpM is an H+ drug antiporter and is the first reported case of an H+ coupled efflux pump in the MATE family. PmpM confers resistance to fluoroquinolones, fradiomycin, benzalkonium chloride, chlorhexidine gluconate, ethidium bromide, tetraphenylphosphonium chloride (TPPCl), and rhodamine 6G. [PMID:14679249] | ARO:3004077 | protein homolog model | Perfect | 927.2 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 451 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001295 (965 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA1361
Search term: norM
Search term: NorM
|
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
|
NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli.
Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, Tsuchiya T
Antimicrob Agents Chemother 1998 Jul;42(7):1778-82
PubMed ID: 9661020
|
An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa.
He GX, Kuroda T, Mima T, Morita Y, Mizushima T, Tsuchiya T
J Bacteriol 2004 Jan;186(1):262-5
PubMed ID: 14679249
|