Pseudomonas aeruginosa PAO1, PA1435

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1435
Name
Replicon chromosome
Genomic location 1562813 - 1563970 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_250126.1
GI 15596632
Affymetrix PA1435_at
Entrez 881806
GenBank AAG04824.1
INSDC AAG04824.1
NCBI Locus Tag PA1435
protein_id(GenBank) gb|AAG04824.1|AE004573_3|gnl|PseudoCAP|PA1435
TIGR NTL03PA01436
UniParc UPI00000C537D
UniProtKB Acc Q9I3R2
UniProtKB ID Q9I3R2_PSEAE
UniRef100 UniRef100_Q4LDT9
UniRef50 UniRef50_Q0K9R0
UniRef90 UniRef90_B7UWB7

Product

Feature Type CDS
Coding Frame 1
Product Name
probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor
Product Name Confidence: Class 3
Synonyms probable RND efflux membrane fusion protein precursor
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.73
Kyte-Doolittle Hydrophobicity Value -0.049
Molecular Weight (kDa) 41.2
Isoelectric Point (pI) 9.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
mexM mexM is the membrane fusion protein of the MexMN-OprM multidrug efflux complex. [PMID:19713238] ARO:3003704 protein homolog model Perfect 709.1 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 417 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001352 (456 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1435

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295