Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2018
|
Name |
mexY
Synonym: mexH Synonym: amrB |
Replicon | chromosome |
Genomic location | 2208169 - 2211306 (- strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 8 transposon mutants in orthologs |
RefSeq | NP_250708.1 |
GI | 15597214 |
Affymetrix | PA2018_at |
Entrez | 878882 |
GenBank | AAG05406.1 |
INSDC | AAG05406.1 |
NCBI Locus Tag | PA2018 |
protein_id(GenBank) | gb|AAG05406.1|AE004628_4|gnl|PseudoCAP|PA2018 |
TIGR | NTL03PA02018 |
UniParc | UPI00000D420B |
UniProtKB Acc | G3XCW2 |
UniProtKB ID | G3XCW2_PSEAE |
UniRef100 | UniRef100_G3XCW2 |
UniRef50 | UniRef50_P31224 |
UniRef90 | UniRef90_G3XCW2 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexY
|
Synonyms |
RND multidrug efflux transporter |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -4.58 |
Kyte-Doolittle Hydrophobicity Value | 0.341 |
Molecular Weight (kDa) | 112.7 |
Isoelectric Point (pI) | 6.24 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
mexY | MexY is the RND-type membrane protein of the efflux complex MexXY-OprM. [PMID:9925549] | ARO:3003033 | protein homolog model | Strict | 1808.1 | 93.79 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 487 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000417 (2093 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2018
Search term: mexY
|
Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.
Moore RA, DeShazer D, Reckseidler S, Weissman A, Woods DE
Antimicrob Agents Chemother 1999 Mar;43(3):465-70
PubMed ID: 10049252
|
MexXY multidrug efflux system of Pseudomonas aeruginosa.
Morita Y, Tomida J, Kawamura Y
Front Microbiol 2012;3:408
PubMed ID: 23233851
|
Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.
Aires JR, Köhler T, Nikaido H, Plésiat P
Antimicrob Agents Chemother 1999 Nov;43(11):2624-8
PubMed ID: 10543738
|
Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa.
Masuda N, Sakagawa E, Ohya S, Gotoh N, Tsujimoto H, Nishino T
Antimicrob Agents Chemother 2000 Sep;44(9):2242-6
PubMed ID: 10952562
|
Induction of the MexXY efflux pump in Pseudomonas aeruginosa is dependent on drug-ribosome interaction.
Jeannot K, Sobel ML, El Garch F, Poole K, Plésiat P
J Bacteriol 2005 Aug;187(15):5341-6
PubMed ID: 16030228
|