Pseudomonas aeruginosa PAO1, PA3587 (metR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3587
Name
metR
Replicon chromosome
Genomic location 4019743 - 4020663 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252277.1
GI 15598783
Affymetrix PA3587_metR_at
DNASU PaCD00007573
Entrez 880220
GenBank AAG06975.1
INSDC AAG06975.1
NCBI Locus Tag PA3587
protein_id(GenBank) gb|AAG06975.1|AE004779_7|gnl|PseudoCAP|PA3587
TIGR NTL03PA03587
UniParc UPI00000C5A7A
UniProtKB Acc Q9HY39
UniProtKB ID Q9HY39_PSEAE
UniRef100 UniRef100_Q9HY39
UniRef50 UniRef50_Q4K712
UniRef90 UniRef90_Q9HY39

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator MetR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.22
Kyte-Doolittle Hydrophobicity Value 0.046
Molecular Weight (kDa) 34.2
Isoelectric Point (pI) 5.63

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 520 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002083 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3587
Search term: metR

Human Homologs

References

Regulation of methionine synthesis in Escherichia coli: effect of the MetR protein on the expression of the metE and metR genes.
Maxon ME, Redfield B, Cai XY, Shoeman R, Fujita K, Fisher W, Stauffer G, Weissbach H, Brot N
Proc Natl Acad Sci U S A 1989 Jan;86(1):85-9
PubMed ID: 2643109
Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR.
Yeung AT, Torfs EC, Jamshidi F, Bains M, Wiegand I, Hancock RE, Overhage J
J Bacteriol 2009 Sep;191(18):5592-602
PubMed ID: 19592586