Pseudomonas aeruginosa PAO1, PA3643 (lpxB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3643
Name
lpxB
Synonym: pgsB
Replicon chromosome
Genomic location 4081045 - 4082181 (- strand)

Cross-References

RefSeq NP_252333.1
GI 15598839
Affymetrix PA3643_lpxB_at
Entrez 880521
GenBank AAG07031.1
INSDC AAG07031.1
NCBI Locus Tag PA3643
protein_id(GenBank) gb|AAG07031.1|AE004784_4|gnl|PseudoCAP|PA3643
TIGR NTL03PA03643
UniParc UPI000012E8CE
UniProtKB Acc Q9HXY8
UniProtKB ID LPXB_PSEAE
UniRef100 UniRef100_B7V7U5
UniRef50 UniRef50_Q0VQE4
UniRef90 UniRef90_A6V1E5

Product

Feature Type CDS
Coding Frame 1
Product Name
lipid A-disaccharide synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 6.60
Kyte-Doolittle Hydrophobicity Value 0.130
Molecular Weight (kDa) 41.3
Isoelectric Point (pI) 9.39

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 383 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002031 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3643
Search term: lpxB

Human Homologs

References

Molecular cloning of the genes for lipid A disaccharide synthase and UDP-N-acetylglucosamine acyltransferase in Escherichia coli.
Crowell DN, Anderson MS, Raetz CR
J Bacteriol 1986 Oct;168(1):152-9
PubMed ID: 3531165
Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase.
Crowell DN, Reznikoff WS, Raetz CR
J Bacteriol 1987 Dec;169(12):5727-34
PubMed ID: 2824445