Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA3644
|
Name |
lpxA
|
Replicon | chromosome |
Genomic location | 4082185 - 4082961 (- strand) |
RefSeq | NP_252334.1 |
GI | 15598840 |
Affymetrix | PA3644_lpxA_at |
Entrez | 880493 |
GenBank | AAG07032.1 |
INSDC | AAG07032.1 |
NCBI Locus Tag | PA3644 |
protein_id(GenBank) | gb|AAG07032.1|AE004784_5|gnl|PseudoCAP|PA3644 |
TIGR | NTL03PA03644 |
UniParc | UPI000012E8B4 |
UniProtKB Acc | Q9X6P4 |
UniProtKB ID | LPXA_PSEAE |
UniRef100 | UniRef100_A6V1E4 |
UniRef50 | UniRef50_P32201 |
UniRef90 | UniRef90_A4XWS9 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
UDP-N-acetylglucosamine acyltransferase
|
Synonyms |
acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | 0.30 |
Kyte-Doolittle Hydrophobicity Value | -0.118 |
Molecular Weight (kDa) | 28.0 |
Isoelectric Point (pI) | 7.05 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
7OKB | TRANSFERASE | 05/17/21 | Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 45 | Pseudomonas aeruginosa | 3.58 | X-RAY DIFFRACTION | 100.0 |
7OK2 | TRANSFERASE | 05/17/21 | Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 3 | Pseudomonas aeruginosa (strain PA7) | 2.89 | X-RAY DIFFRACTION | 100.0 |
7OKA | TRANSFERASE | 05/17/21 | Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 14 | Pseudomonas aeruginosa (strain PA7) | 2.74 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 433 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002030 (537 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA3644
Search term: lpxA
Search term: UDP-N-acetylglucosamine acyltransferase
|
First committed step of lipid A biosynthesis in Escherichia coli: sequence of the lpxA gene.
Coleman J, Raetz CR
J Bacteriol 1988 Mar;170(3):1268-74
PubMed ID: 3277952
|
Structural characterization of the lipid A component of Pseudomonas aeruginosa wild-type and rough mutant lipopolysaccharides.
Kulshin VA, Zähringer U, Lindner B, Jäger KE, Dmitriev BA, Rietschel ET
Eur J Biochem 1991 Jun 15;198(3):697-704
PubMed ID: 1904818
|
A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase.
Raetz CR, Roderick SL
Science 1995 Nov 10;270(5238):997-1000
PubMed ID: 7481807
|