Pseudomonas aeruginosa PAO1, PA3652 (uppS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3652
Name
uppS
Synonym: yaeS
Replicon chromosome
Genomic location 4090900 - 4091655 (- strand)

Cross-References

RefSeq NP_252342.1
GI 15598848
Affymetrix PA3652_uppS_at
Entrez 880553
GenBank AAG07040.1
INSDC AAG07040.1
NCBI Locus Tag PA3652
protein_id(GenBank) gb|AAG07040.1|AE004785_4|gnl|PseudoCAP|PA3652
TIGR NTL03PA03652
UniParc UPI00000C5AA4
UniProtKB Acc Q9HXY2
UniProtKB ID UPPS_PSEAE
UniRef100 UniRef100_Q9HXY2
UniRef50 UniRef50_Q9HXY2
UniRef90 UniRef90_Q9HXY2

Product

Feature Type CDS
Coding Frame 1
Product Name
undecaprenyl pyrophosphate synthetase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 1.30
Kyte-Doolittle Hydrophobicity Value -0.199
Molecular Weight (kDa) 28.0
Isoelectric Point (pI) 7.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 658 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002022 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3652
Search term: uppS

Human Homologs

Ensembl 110, assembly GRCh38.p14
dehydrodolichyl diphosphate synthase subunit [Source:HGNC Symbol;Acc:HGNC:20603]
E-value: 3.1e-34
Percent Identity: 34.3

References

Use of genomics to identify bacterial undecaprenyl pyrophosphate synthetase: cloning, expression, and characterization of the essential uppS gene.
Apfel CM, Takács B, Fountoulakis M, Stieger M, Keck W
J Bacteriol 1999 Jan;181(2):483-92
PubMed ID: 9882662