Pseudomonas aeruginosa PAO1, PA3748

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3748
Name
Synonym: yfjD
Replicon chromosome
Genomic location 4199656 - 4200948 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252437.1
GI 15598943
Affymetrix PA3748_at
Entrez 880304
GenBank AAG07135.1
INSDC AAG07135.1
NCBI Locus Tag PA3748
protein_id(GenBank) gb|AAG07135.1|AE004793_12|gnl|PseudoCAP|PA3748
TIGR NTL03PA03748
UniParc UPI00000C5AEF
UniProtKB Acc Q9HXP6
UniProtKB ID Q9HXP6_PSEAE
UniRef100 UniRef100_Q9HXP6
UniRef50 UniRef50_A0A024HCY5
UniRef90 UniRef90_A0A077JMH8

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Charge (pH 7) -14.29
Kyte-Doolittle Hydrophobicity Value 0.050
Molecular Weight (kDa) 47.9
Isoelectric Point (pI) 4.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 599 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001934 (527 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3748

Human Homologs

Ensembl 110, assembly GRCh38.p14
cyclin and CBS domain divalent metal cation transport mediator 4 [Source:HGNC Symbol;Acc:HGNC:105]
E-value: 1.8e-10
Percent Identity: 25.6

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295