Pseudomonas aeruginosa PAK, PAK_00611 (pilU)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAK - Assembly GCF_000408865.1
GCF_000408865.1|latest |
| Locus Tag |
PAK_00611
|
| Name |
pilU
|
| Replicon | chromosome |
| Genomic location | 658719 - 659753 (+ strand) |
Cross-References
| RefSeq | WP_003084552.1 |
| GI | 489175024 |
| NCBI Locus Tag | PAK_00611 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
twitching motility protein PilU
|
| Synonyms |
twitching motility protein PilT |
| Evidence for Translation | |
| Charge (pH 7) | -0.64 |
| Kyte-Doolittle Hydrophobicity Value | -0.114 |
| Molecular Weight (kDa) | 38.0 |
| Isoelectric Point (pI) | 6.87 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 3JVU | ATP binding protein | 09/17/09 | Crystal structure of unliganded P. aeruginosa PilT | Pseudomonas aeruginosa | 3.1 | X-RAY DIFFRACTION | 100.0 |
| 3JVV | ATP binding protein | 09/17/09 | Crystal Structure of P. aeruginosa PilT with bound AMP-PCP | Pseudomonas aeruginosa | 2.6 | X-RAY DIFFRACTION | 100.0 |
Virulence Evidence
| Source 1 | |
| Database | PseudoCAP |
| Category | Type IV pili biosynthesis |
| Evidence |
|
| Host Organism | |
| Notes | |
| Reference | 10377148 |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000386 (535 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PAK_00611
Search term: pilU
Search term: twitching motility protein PilU
|
Human Homologs
References
|
Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia.
Comolli JC, Hauser AR, Waite L, Whitchurch CB, Mattick JS, Engel JN
Infect Immun 1999 Jul;67(7):3625-30
PubMed ID: 10377148
|