Pseudomonas aeruginosa PAK, PAK_01361 (suhB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa PAK - Assembly GCF_000408865.1
GCF_000408865.1|latest
Locus Tag
PAK_01361
Name
suhB
Replicon chromosome
Genomic location 1451534 - 1452349 (- strand)

Cross-References

RefSeq WP_003092845.1
GI 489183406
NCBI Locus Tag PAK_01361

Product

Feature Type CDS
Coding Frame 1
Product Name
SuhB
Product Name Confidence: Class 1
Synonyms inositol monophosphatase
Evidence for Translation
Charge (pH 7) -1.38
Kyte-Doolittle Hydrophobicity Value -0.106
Molecular Weight (kDa) 29.5
Isoelectric Point (pI) 6.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Virulence Evidence

Source 1
Database PseudoCAP
Category Type III Secretion Regulators
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse model of acute pneumonia
Reference 24169572

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001848 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAK_01361
Search term: suhB
Search term: SuhB

Human Homologs

Ensembl 110, assembly GRCh38.p14
inositol monophosphatase 2 [Source:HGNC Symbol;Acc:HGNC:6051]
E-value: 1.8e-35
Percent Identity: 37.2

References

SuhB is a regulator of multiple virulence genes and essential for pathogenesis of Pseudomonas aeruginosa.
Li K, Xu C, Jin Y, Sun Z, Liu C, Shi J, Chen G, Chen R, Jin S, Wu W
mBio 2013 Oct 29;4(6):e00419-13
PubMed ID: 24169572