Pseudomonas aeruginosa PAO1, PA0081 (fha1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0081
Name
fha1
Replicon chromosome
Genomic location 98263 - 99756 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_248771.1
GI 15595279
Affymetrix PA0081_at
Entrez 879413
GenBank AAG03471.1
INSDC AAG03471.1
NCBI Locus Tag PA0081
protein_id(GenBank) gb|AAG03471.1|AE004447_4|gnl|PseudoCAP|PA0081
TIGR NTL03PA00082
UniParc UPI00000C4F22
UniProtKB Acc Q9I751
UniProtKB ID Q9I751_PSEAE
UniRef100 UniRef100_Q9I751
UniRef50 UniRef50_Q4K3P0
UniRef90 UniRef90_Q9I751

Product

Feature Type CDS
Coding Frame 1
Product Name
Fha1
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -12.39
Kyte-Doolittle Hydrophobicity Value -0.398
Molecular Weight (kDa) 53.3
Isoelectric Point (pI) 5.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0334
Category Hcp secretion island-1 encoded type VI secretion system (H-T6SS)
Evidence ECO:0000305
curator inference used in manual assertion
Host Organism
Notes
Reference 16763151

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 65 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000080 (840 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0081
Search term: fha1
Search term: Fha1

Human Homologs

Ensembl 86, assembly GRCh38.p7
protein phosphatase 1 regulatory subunit 13 like [Source:HGNC Symbol;Acc:HGNC:18838]
E-value: 1.2e-08
Percent Identity: 36.3

References

A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria.
Hood RD, Singh P, Hsu F, Güvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, Mougous JD
Cell Host Microbe 2010 Jan;7(1):25-37
PubMed ID: 20114026