Pseudomonas aeruginosa PAO1, PA0130 (bauC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0130
Name
bauC
Replicon chromosome
Genomic location 147561 - 149054 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_248820.1
GI 15595328
Affymetrix PA0130_at
Entrez 880875
GenBank AAG03520.1
INSDC AAG03520.1
NCBI Locus Tag PA0130
protein_id(GenBank) gb|AAG03520.1|AE004451_1|gnl|PseudoCAP|PA0130
TIGR NTL03PA00131
UniParc UPI00000C4F52
UniProtKB Acc Q9I702
UniProtKB ID BAUC_PSEAE
UniRef100 UniRef100_Q9I702
UniRef50 UniRef50_Q9I702
UniRef90 UniRef90_Q9I702

Product

Feature Type CDS
Coding Frame 1
Product Name
3-Oxopropanoate dehydrogenase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.37
Kyte-Doolittle Hydrophobicity Value -0.014
Molecular Weight (kDa) 53.3
Isoelectric Point (pI) 5.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5TJR OXIDOREDUCTASE 10/05/16 X-ray Crystal structure of a methylmalonate semialdehyde dehydrogenase from Pseudomonas sp. AAC PSEUDOMONAS SP. AAC 2.95 X-RAY DIFFRACTION 91.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 599 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000128 (548 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0130
Search term: bauC

Human Homologs

Ensembl 97, assembly GRCh38.p12
aldehyde dehydrogenase 6 family member A1 [Source:HGNC Symbol;Acc:HGNC:7179]
E-value: 2.0e-126
Percent Identity: 45.6

References

Functional characterization of seven γ-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and β-Alanine utilization in Pseudomonas aeruginosa PAO1.
Yao X, He W, Lu CD
J. Bacteriol. 2011 Aug;193(15):3923-30
PubMed ID: 21622750