Pseudomonas aeruginosa PAO1, PA0331 (ilvA1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0331
Name
ilvA1
Replicon chromosome
Genomic location 372091 - 373605 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249022.1
GI 15595528
Affymetrix PA0331_ilvA1_at
Entrez 879435
GenBank AAG03720.1
INSDC AAG03720.1
NCBI Locus Tag PA0331
protein_id(GenBank) gb|AAG03720.1|AE004471_3|gnl|PseudoCAP|PA0331
TIGR NTL03PA00332
UniParc UPI00000C500E
UniProtKB Acc Q9I6G0
UniProtKB ID Q9I6G0_PSEAE
UniRef100 UniRef100_W0YMS1
UniRef50 UniRef50_Q9I418
UniRef90 UniRef90_A6UYD3

Product

Feature Type CDS
Coding Frame 1
Product Name
threonine dehydratase, biosynthetic
Product Name Confidence: Class 2
Synonyms threonine deaminase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -5.01
Kyte-Doolittle Hydrophobicity Value -0.150
Molecular Weight (kDa) 55.4
Isoelectric Point (pI) 6.47

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 636 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000323 (865 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0331
Search term: ilvA1

Human Homologs

Ensembl 97, assembly GRCh38.p12
serine racemase [Source:HGNC Symbol;Acc:HGNC:14398]
E-value: 8.2e-43
Percent Identity: 37.3

References

The complete nucleotide sequence of the ilvGMEDA cluster of Escherichia coli K-12.
Cox JL, Cox BJ, Fidanza V, Calhoun DH
Gene 1987;56(2-3):185-98
PubMed ID: 3315862
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994