Pseudomonas aeruginosa PAO1, PA0512 (nirH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0512
Name
nirH
Synonym: nirH
Replicon chromosome
Genomic location 574590 - 575105 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249203.1
GI 15595709
Affymetrix PA0512_at
DNASU PaCD00006214
Entrez 877584
GenBank AAG03901.1
INSDC AAG03901.1
NCBI Locus Tag PA0512
protein_id(GenBank) gb|AAG03901.1|AE004488_5|gnl|PseudoCAP|PA0512
TIGR NTL03PA00513
UniParc UPI00000C4EC4
UniProtKB Acc P95415
UniProtKB ID NIRH_PSEAE
UniRef100 UniRef100_P95415
UniRef50 UniRef50_P95415
UniRef90 UniRef90_P95415

Product

Feature Type CDS
Coding Frame 1
Product Name
NirH
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 9.07
Kyte-Doolittle Hydrophobicity Value -0.233
Molecular Weight (kDa) 19.6
Isoelectric Point (pI) 10.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 121 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000497 (355 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0512
Search term: nirH
Search term: NirH

Human Homologs

References

Resolution of the nirD locus for heme d1 synthesis of cytochrome cd1 (respiratory nitrite reductase) from Pseudomonas stutzeri.
Palmedo G, Seither P, Körner H, Matthews JC, Burkhalter RS, Timkovich R, Zumft WG
Eur J Biochem 1995 Sep 15;232(3):737-46
PubMed ID: 7588711
Gene cluster for dissimilatory nitrite reductase (nir) from Pseudomonas aeruginosa: sequencing and identification of a locus for heme d1 biosynthesis.
Kawasaki S, Arai H, Kodama T, Igarashi Y
J Bacteriol 1997 Jan;179(1):235-42
PubMed ID: 8982003