Pseudomonas aeruginosa PAO1, PA0677 (hxcW)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0677
Name
hxcW
Replicon chromosome
Genomic location 736456 - 737097 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentHxc proteins are involved in the secretion of alkaline phosphatase. hxc gene cluster is under phosphate regulation. General secretory pathway protein J family.

Cross-References

RefSeq NP_249368.1
GI 15595874
Affymetrix PA0677_at
DNASU PaCD00006309
Entrez 880651
GenBank AAG04066.1
INSDC AAG04066.1
NCBI Locus Tag PA0677
protein_id(GenBank) gb|AAG04066.1|AE004503_4|gnl|PseudoCAP|PA0677
TIGR NTL03PA00678
UniParc UPI00000C50F6
UniProtKB Acc Q9I5P8
UniProtKB ID Q9I5P8_PSEAE
UniRef100 UniRef100_Q9I5P8
UniRef50 UniRef50_A0A077JQ63
UniRef90 UniRef90_A0A077JQ63

Product

Feature Type CDS
Coding Frame 1
Product Name
HxcW
Product Name Confidence: Class 1
Synonyms HxcW putative pseudopilin
Evidence for Translation
Charge (pH 7) 10.48
Kyte-Doolittle Hydrophobicity Value -0.168
Molecular Weight (kDa) 23.6
Isoelectric Point (pI) 11.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 33 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000656 (743 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0677
Search term: hxcW
Search term: HxcW

Human Homologs

References

A novel type II secretion system in Pseudomonas aeruginosa.
Ball G, Durand E, Lazdunski A, Filloux A
Mol Microbiol 2002 Jan;43(2):475-85
PubMed ID: 11985723
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295