Pseudomonas aeruginosa PAO1, PA0681 (hxcT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0681
Name
hxcT
Replicon chromosome
Genomic location 738719 - 739168 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentThe fifth residue of the mature sequence is a glutamate, which seems important in the methylation of this class of proteins.hxc gene cluster is under phosphate regulation. Belongs to the GspG family (general secretory pathway).

Cross-References

RefSeq NP_249372.1
GI 15595878
Affymetrix PA0681_at
DNASU PaCD00006312
Entrez 879708
GenBank AAG04070.1
INSDC AAG04070.1
NCBI Locus Tag PA0681
protein_id(GenBank) gb|AAG04070.1|AE004503_8|gnl|PseudoCAP|PA0681
TIGR NTL03PA00682
UniParc UPI00000C50FA
UniProtKB Acc Q9I5P4
UniProtKB ID Q9I5P4_PSEAE
UniRef100 UniRef100_Q9I5P4
UniRef50 UniRef50_P15746
UniRef90 UniRef90_A6VAT5

Product

Feature Type CDS
Coding Frame 1
Product Name
HxcT
Product Name Confidence: Class 1
Synonyms HxcT pseudopilin
Evidence for Translation
Charge (pH 7) 0.23
Kyte-Doolittle Hydrophobicity Value -0.219
Molecular Weight (kDa) 16.2
Isoelectric Point (pI) 7.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 274 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000660 (797 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0681
Search term: hxcT
Search term: HxcT

Human Homologs

References

A novel type II secretion system in Pseudomonas aeruginosa.
Ball G, Durand E, Lazdunski A, Filloux A
Mol Microbiol 2002 Jan;43(2):475-85
PubMed ID: 11985723
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295