Pseudomonas aeruginosa PAO1, PA0908 (alpB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0908
Name
alpB
Replicon chromosome
Genomic location 993409 - 993783 (+ strand)

Cross-References

RefSeq NP_249599.1
GI 15596105
Affymetrix PA0908_at
DNASU PaCD00006419
Entrez 878331
GenBank AAG04297.1
INSDC AAG04297.1
NCBI Locus Tag PA0908
protein_id(GenBank) gb|AAG04297.1|AE004525_5|gnl|PseudoCAP|PA0908
TIGR NTL03PA00909
UniParc UPI00000C51AF
UniProtKB Acc Q9I549
UniProtKB ID Q9I549_PSEAE
UniRef100 UniRef100_W0YKI2
UniRef50 UniRef50_Q02I68
UniRef90 UniRef90_Q02I68

Product

Feature Type CDS
Coding Frame 1
Product Name
AlpB
Product Name Confidence: Class 1
CommentHolin-like protein that is required for lysis by the Alp pathway
Evidence for Translation
Charge (pH 7) 1.95
Kyte-Doolittle Hydrophobicity Value 0.448
Molecular Weight (kDa) 12.7
Isoelectric Point (pI) 9.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 12 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000874 (311 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0908
Search term: alpB
Search term: AlpB

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics.
Alvarez-Ortega C, Wiegand I, Olivares J, Hancock RE, Martínez JL
Antimicrob. Agents Chemother. 2010 Oct;54(10):4159-67
PubMed ID: 20679510
A self-lysis pathway that enhances the virulence of a pathogenic bacterium.
McFarland KA, Dolben EL, LeRoux M, Kambara TK, Ramsey KM, Kirkpatrick RL, Mougous JD, Hogan DA, Dove SL
Proc. Natl. Acad. Sci. U.S.A. 2015 Jul;112(27):8433-8
PubMed ID: 26100878