Pseudomonas aeruginosa PAO1, PA0909 (alpC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0909
Name
alpC
Replicon chromosome
Genomic location 993776 - 994051 (+ strand)

Cross-References

RefSeq NP_249600.1
GI 15596106
Affymetrix PA0909_i_at
DNASU PaCD00006420
Entrez 882062
GenBank AAG04298.1
INSDC AAG04298.1
NCBI Locus Tag PA0909
protein_id(GenBank) gb|AAG04298.1|AE004525_6|gnl|PseudoCAP|PA0909
TIGR NTL03PA00910
UniParc UPI00000C51B0
UniProtKB Acc Q9I548
UniProtKB ID Q9I548_PSEAE
UniRef100 UniRef100_W0YMR7
UniRef50 UniRef50_A6VA65
UniRef90 UniRef90_B7UY25

Product

Feature Type CDS
Coding Frame 1
Product Name
AlpC
Product Name Confidence: Class 1
CommentProbable anti-holin of the Alp lysis pathway
Evidence for Translation
Charge (pH 7) 7.30
Kyte-Doolittle Hydrophobicity Value 1.001
Molecular Weight (kDa) 9.9
Isoelectric Point (pI) 9.92

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 15 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000875 (311 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0909
Search term: alpC
Search term: AlpC

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
The complete nucleotide sequence of phi CTX, a cytotoxin-converting phage of Pseudomonas aeruginosa: implications for phage evolution and horizontal gene transfer via bacteriophages.
Nakayama K, Kanaya S, Ohnishi M, Terawaki Y, Hayashi T
Mol. Microbiol. 1999 Jan;31(2):399-419
PubMed ID: 10027959
A self-lysis pathway that enhances the virulence of a pathogenic bacterium.
McFarland KA, Dolben EL, LeRoux M, Kambara TK, Ramsey KM, Kirkpatrick RL, Mougous JD, Hogan DA, Dove SL
Proc. Natl. Acad. Sci. U.S.A. 2015 Jul;112(27):8433-8
PubMed ID: 26100878