Pseudomonas aeruginosa PAO1, PA1056 (shaC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1056
Name
shaC
Synonym: phaD
Replicon chromosome
Genomic location 1145197 - 1146696 (+ strand)
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249747.1
GI 15596253
Affymetrix PA1056_at
Entrez 881220
GenBank AAG04445.1
INSDC AAG04445.1
NCBI Locus Tag PA1056
protein_id(GenBank) gb|AAG04445.1|AE004537_10|gnl|PseudoCAP|PA1056
TIGR NTL03PA01057
UniParc UPI00000C522A
UniProtKB Acc Q9I4R8
UniProtKB ID Q9I4R8_PSEAE
UniRef100 UniRef100_Q9I4R8
UniRef50 UniRef50_B3PFD2
UniRef90 UniRef90_Q9I4R8

Product

Feature Type CDS
Coding Frame 1
Product Name
ShaC
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 9.12
Kyte-Doolittle Hydrophobicity Value 0.993
Molecular Weight (kDa) 52.3
Isoelectric Point (pI) 9.77

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 553 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001018 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1056
Search term: shaC
Search term: ShaC

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Characterization of a multigene-encoded sodium/hydrogen antiporter (sha) from Pseudomonas aeruginosa: its involvement in pathogenesis.
Kosono S, Haga K, Tomizawa R, Kajiyama Y, Hatano K, Takeda S, Wakai Y, Hino M, Kudo T
J Bacteriol 2005 Aug;187(15):5242-8
PubMed ID: 16030218