Pseudomonas aeruginosa PAO1, PA1256 (lhpO)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 1364499 - 1365221 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs


RefSeq NP_249947.1
GI 15596453
Affymetrix PA1256_at
DNASU PaCD00006581
Entrez 881300
GenBank AAG04645.1
INSDC AAG04645.1
NCBI Locus Tag PA1256
protein_id(GenBank) gb|AAG04645.1|AE004555_5|gnl|PseudoCAP|PA1256
UniParc UPI00000C52D2
UniProtKB Acc Q9I488
UniRef100 UniRef100_Q9I488
UniRef50 UniRef50_P10346
UniRef90 UniRef90_W0WK36


Feature Type CDS
Coding Frame 1
Product Name
ABC transporter ATP-binding protein, LhpO
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 1.41
Kyte-Doolittle Hydrophobicity Value -0.047
Molecular Weight (kDa) 26.5
Isoelectric Point (pI) 7.78

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001207 (482 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA1256
Search term: lhpO

Human Homologs

Ensembl 86, assembly GRCh38.p7
ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45]
E-value: 2.4e-26
Percent Identity: 34.6

Transposon Insertions in PAO1

Type Confirmed ISlacZ/hah insertion site
Mutant ID UWGC: 18097
Genomic Position 1365068
Position in ORF 570(723)
Reference 14617778
Type ISlacZ/hah insertion site
Mutant ID UWGC: 12625
Genomic Position 1364827
Position in ORF 329(723)
Reference 14617778

Transposon Insertions in Orthologs

Type MAR2xT7 transposon (wild type background) insertion site
Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag PA14_47960
Mutant ID PA14NR: 53130
Genomic Position 4269843
Position in ORF 470(723)
Reference 16477005


Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium.
Higgins CF, Haag PD, Nikaido K, Ardeshir F, Garcia G, Ames GF.
Nature. 1982 Aug 19;298(5876):723-7.
PubMed ID: 7050725
Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G(1), Lu CD(2).
Microbiology. 2016 Jul;162(7):1232-42.
PubMed ID: 27145750
High-throughput phenotypic characterization of Pseudomonas aeruginosa membrane transport genes.
Johnson DA, Tetu SG, Phillippy K, Chen J, Ren Q, Paulsen IT.
PLoS Genet. 2008 Oct 3;4(10):e1000211.
PubMed ID: 18833300