Pseudomonas aeruginosa PAO1, PA1258 (lhpM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1258
Name
lhpM
Replicon chromosome
Genomic location 1365873 - 1366538 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249949.1
GI 15596455
Affymetrix PA1258_at
DNASU PaCD00006583
Entrez 881324
GenBank AAG04647.1
INSDC AAG04647.1
NCBI Locus Tag PA1258
protein_id(GenBank) gb|AAG04647.1|AE004555_7|gnl|PseudoCAP|PA1258
TIGR NTL03PA01259
UniParc UPI00000C52D4
UniProtKB Acc Q9I486
UniProtKB ID Q9I486_PSEAE
UniRef100 UniRef100_W1MMN7
UniRef50 UniRef50_W1MMN7
UniRef90 UniRef90_W1MMN7

Product

Feature Type CDS
Coding Frame 1
Product Name
Permease of ABC transporter, LhpM
Product Name Confidence: Class 1
Synonyms probable permease of ABC transporter
Evidence for Translation
Charge (pH 7) 9.46
Kyte-Doolittle Hydrophobicity Value 0.748
Molecular Weight (kDa) 24.4
Isoelectric Point (pI) 10.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 442 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001209 (341 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1258
Search term: lhpM

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Opine transport genes in the octopine (occ) and nopaline (noc) catabolic regions in Ti plasmids of Agrobacterium tumefaciens.
Zanker H, von Lintig J, Schröder J
J Bacteriol 1992 Feb;174(3):841-9
PubMed ID: 1732218
Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G, Lu CD
Microbiology (Reading) 2016 Jul;162(7):1232-1242
PubMed ID: 27145750
High-throughput phenotypic characterization of Pseudomonas aeruginosa membrane transport genes.
Johnson DA, Tetu SG, Phillippy K, Chen J, Ren Q, Paulsen IT
PLoS Genet 2008 Oct 3;4(10):e1000211
PubMed ID: 18833300