Pseudomonas aeruginosa PAO1, PA1258 (lhpM)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 1365873 - 1366538 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs


RefSeq NP_249949.1
GI 15596455
Affymetrix PA1258_at
DNASU PaCD00006583
Entrez 881324
GenBank AAG04647.1
INSDC AAG04647.1
NCBI Locus Tag PA1258
protein_id(GenBank) gb|AAG04647.1|AE004555_7|gnl|PseudoCAP|PA1258
UniParc UPI00000C52D4
UniProtKB Acc Q9I486
UniRef100 UniRef100_W1MMN7
UniRef50 UniRef50_W1MMN7
UniRef90 UniRef90_W1MMN7


Feature Type CDS
Coding Frame 1
Product Name
Permease of ABC transporter, LhpM
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 9.46
Kyte-Doolittle Hydrophobicity Value 0.748
Molecular Weight (kDa) 24.4
Isoelectric Point (pI) 10.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 442 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001209 (353 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA1258
Search term: lhpM

Transposon Insertions in PAO1

Type ISphoA/hah insertion site
Mutant ID UWGC: 47517
Genomic Position 1366301
Position in ORF 429(666)
Reference 14617778
Type Confirmed ISphoA/hah insertion site
Mutant ID UWGC: 50355
Genomic Position 1366142
Position in ORF 270(666)
Reference 14617778

Transposon Insertions in Orthologs

Type MAR2xT7 transposon (wild type background) insertion site
Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag PA14_47940
Mutant ID PA14NR: 29019
Genomic Position 4268067
Position in ORF 11(666)
Reference 16477005


Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE.
Genome Res. 2005 Feb;15(2):321-9.
PubMed ID: 15687295
Opine transport genes in the octopine (occ) and nopaline (noc) catabolic regions in Ti plasmids of Agrobacterium tumefaciens.
Zanker H, von Lintig J, Schroder J.
J Bacteriol. 1992 Feb;174(3):841-9.
PubMed ID: 1732218
Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G(1), Lu CD(2).
Microbiology. 2016 Jul;162(7):1232-42.
PubMed ID: 27145750
High-throughput phenotypic characterization of Pseudomonas aeruginosa membrane transport genes.
Johnson DA, Tetu SG, Phillippy K, Chen J, Ren Q, Paulsen IT.
PLoS Genet. 2008 Oct 3;4(10):e1000211.
PubMed ID: 18833300