Pseudomonas aeruginosa PAO1, PA1259 (lhpH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1259
Name
lhpH
Replicon chromosome
Genomic location 1366538 - 1368280 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249950.1
GI 15596456
Affymetrix PA1259_at
Entrez 881330
GenBank AAG04648.1
INSDC AAG04648.1
NCBI Locus Tag PA1259
protein_id(GenBank) gb|AAG04648.1|AE004555_8|gnl|PseudoCAP|PA1259
TIGR NTL03PA01260
UniParc UPI00000C52D5
UniProtKB Acc Q9I485
UniProtKB ID Q9I485_PSEAE
UniRef100 UniRef100_Q9I485
UniRef50 UniRef50_Q9I485
UniRef90 UniRef90_Q9I485

Product

Feature Type CDS
Coding Frame 1
Product Name
LhpH
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -4.31
Kyte-Doolittle Hydrophobicity Value 0.043
Molecular Weight (kDa) 61.8
Isoelectric Point (pI) 6.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 90 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001210 (340 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1259
Search term: lhpH
Search term: LhpH

Human Homologs

References

Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G, Lu CD
Microbiology (Reading) 2016 Jul;162(7):1232-1242
PubMed ID: 27145750