Pseudomonas aeruginosa PAO1, PA1260 (lhpP)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 1368339 - 1369160 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs


RefSeq NP_249951.1
GI 15596457
Affymetrix PA1260_at
DNASU PaCD00006584
Entrez 881316
GenBank AAG04649.1
INSDC AAG04649.1
NCBI Locus Tag PA1260
protein_id(GenBank) gb|AAG04649.1|AE004555_9|gnl|PseudoCAP|PA1260
UniParc UPI00000C52D6
UniProtKB Acc Q9I484
UniRef100 UniRef100_W0YLE2
UniRef50 UniRef50_I3TTK9
UniRef90 UniRef90_A6V8V1


Feature Type CDS
Coding Frame 1
Product Name
ABC transporter periplasmic-binding protein, LhpP
Product Name Confidence: Class 1
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.86
Kyte-Doolittle Hydrophobicity Value -0.069
Molecular Weight (kDa) 29.1
Isoelectric Point (pI) 5.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 430 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001211 (1040 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA1260
Search term: lhpP

Transposon Insertions in PAO1

Type Confirmed ISlacZ/hah insertion site
Mutant ID UWGC: 9238
Genomic Position 1368365
Position in ORF 27(822)
Reference 14617778
Type ISphoA/hah insertion site
Mutant ID UWGC: 32326
Genomic Position 1368839
Position in ORF 501(822)
Reference 14617778
Type ISphoA/hah insertion site
Mutant ID UWGC: 44675
Genomic Position 1368883
Position in ORF 545(822)
Reference 14617778

Transposon Insertions in Orthologs

Type MAR2xT7 transposon (wild type background) insertion site
Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag PA14_47920
Mutant ID PA14NR: 40011
Genomic Position 4266054
Position in ORF 620(822)
Reference 16477005


Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE.
Genome Res. 2005 Feb;15(2):321-9.
PubMed ID: 15687295
Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G(1), Lu CD(2).
Microbiology. 2016 Jul;162(7):1232-42.
PubMed ID: 27145750
High-throughput phenotypic characterization of Pseudomonas aeruginosa membrane transport genes.
Johnson DA, Tetu SG, Phillippy K, Chen J, Ren Q, Paulsen IT.
PLoS Genet. 2008 Oct 3;4(10):e1000211.
PubMed ID: 18833300