Pseudomonas aeruginosa PAO1, PA1261 (lhpR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1261
Name
lhpR
Replicon chromosome
Genomic location 1369418 - 1370092 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249952.1
GI 15596458
Affymetrix PA1261_at
Entrez 881351
GenBank AAG04650.1
INSDC AAG04650.1
NCBI Locus Tag PA1261
protein_id(GenBank) gb|AAG04650.1|AE004555_10|gnl|PseudoCAP|PA1261
TIGR NTL03PA01262
UniParc UPI00000C52D7
UniProtKB Acc Q9I483
UniProtKB ID Q9I483_PSEAE
UniRef100 UniRef100_U8N3V3
UniRef50 UniRef50_G8MBA7
UniRef90 UniRef90_A6V8U9

Product

Feature Type CDS
Coding Frame 1
Product Name
Transcriptional regulator, LhpR
Product Name Confidence: Class 1
Synonyms probable transcriptional regulator
Evidence for Translation
Charge (pH 7) 10.27
Kyte-Doolittle Hydrophobicity Value -0.321
Molecular Weight (kDa) 24.7
Isoelectric Point (pI) 9.83

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 396 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001212 (457 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1261
Search term: lhpR

Human Homologs

References

Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G, Lu CD
Microbiology (Reading) 2016 Jul;162(7):1232-1242
PubMed ID: 27145750