Pseudomonas aeruginosa PAO1, PA1266 (lhpE)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 1374844 - 1376097 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs


RefSeq NP_249957.1
GI 15596463
Affymetrix PA1266_at
Entrez 881372
GenBank AAG04655.1
INSDC AAG04655.1
NCBI Locus Tag PA1266
protein_id(GenBank) gb|AAG04655.1|AE004556_5|gnl|PseudoCAP|PA1266
UniParc UPI00000C52DC
UniProtKB Acc Q9I478
UniRef100 UniRef100_Q9I478
UniRef50 UniRef50_A0A0D0TAV2
UniRef90 UniRef90_Q9I478


Feature Type CDS
Coding Frame 1
Product Name
D-hydroxyproline dehydrogenase alpha-subunit, LphE
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 12.35
Kyte-Doolittle Hydrophobicity Value -0.018
Molecular Weight (kDa) 44.1
Isoelectric Point (pI) 9.25

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Unknown (This protein may have multiple localization sites) Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 201 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001216 (365 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA1266
Search term: lhpE

Transposon Insertions in PAO1

Type ISphoA/hah insertion site
Mutant ID UWGC: 47192
Genomic Position 1375900
Position in ORF 1057(1254)
Reference 14617778
Type ISphoA/hah insertion site
Mutant ID UWGC: 37450
Genomic Position 1375694
Position in ORF 851(1254)
Reference 14617778

Transposon Insertions in Orthologs

Type MAR2xT7 transposon (wild type background) insertion site
Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag PA14_47860
Mutant ID PA14NR: 40190
Genomic Position 4259643
Position in ORF 1145(1254)
Reference 16477005


Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE.
Genome Res. 2005 Feb;15(2):321-9.
PubMed ID: 15687295
Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G(1), Lu CD(2).
Microbiology. 2016 Jul;162(7):1232-42.
PubMed ID: 27145750
Identification and characterization of D-hydroxyproline dehydrogenase and Delta1-pyrroline-4-hydroxy-2-carboxylate deaminase involved in novel L-hydroxyproline metabolism of bacteria: metabolic convergent evolution.
Watanabe S(1), Morimoto D, Fukumori F, Shinomiya H, Nishiwaki H, Kawano-Kawada M, Sasai Y, Tozawa Y, Watanabe Y.
J Biol Chem. 2012 Sep 21;287(39):32674-88.
PubMed ID: 22833679