Pseudomonas aeruginosa PAO1, PA1267 (lhpB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA1267
Name
lhpB
Replicon chromosome
Genomic location 1376327 - 1377442 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249958.1
GI 15596464
Affymetrix PA1267_at
Entrez 881399
GenBank AAG04656.1
INSDC AAG04656.1
NCBI Locus Tag PA1267
protein_id(GenBank) gb|AAG04656.1|AE004556_6|gnl|PseudoCAP|PA1267
TIGR NTL03PA01268
UniParc UPI00000C52DD
UniProtKB Acc Q9I477
UniProtKB ID Q9I477_PSEAE
UniRef100 UniRef100_Q9I477
UniRef50 UniRef50_A0A022NPY8
UniRef90 UniRef90_A0A022NPY8

Product

Feature Type CDS
Coding Frame 1
Product Name
D-hydroxyproline dehydrogenase beta-subunit, LphB
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -1.22
Kyte-Doolittle Hydrophobicity Value 0.016
Molecular Weight (kDa) 39.1
Isoelectric Point (pI) 6.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 367 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001217 (411 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1267
Search term: lhpB

Transposon Insertions in PAO1

Type ISlacZ/hah insertion site
Mutant ID UWGC: 6014
Genomic Position 1376868
Position in ORF 542(1116)
Reference 14617778
Type ISphoA/hah insertion site
Mutant ID UWGC: 46456
Genomic Position 1377045
Position in ORF 719(1116)
Reference 14617778

Transposon Insertions in Orthologs

References

Molecular characterization of LhpR in control of hydroxyproline catabolism and transport in Pseudomonas aeruginosa PAO1.
Li G, Lu CD
Microbiology (Reading, Engl.) 2016 Jul;162(7):1232-42
PubMed ID: 27145750
Identification and characterization of D-hydroxyproline dehydrogenase and Delta1-pyrroline-4-hydroxy-2-carboxylate deaminase involved in novel L-hydroxyproline metabolism of bacteria: metabolic convergent evolution.
Watanabe S, Morimoto D, Fukumori F, Shinomiya H, Nishiwaki H, Kawano-Kawada M, Sasai Y, Tozawa Y, Watanabe Y
J. Biol. Chem. 2012 Sep;287(39):32674-88
PubMed ID: 22833679